Fluoride elicits a complex, dose-dependent suite of responses from bone tissue, including physicochemical and cellular changes and alteration of the material and mechanical properties of bone. Some representative research in this field:
D Chachra, APGF Vieira, MD Grynpas, Fluoride and mineralized tissues [review paper] (2008) Critical Reviews in Biomedical Engineering 36:183-233.
D Chachra, H Limeback, TL Willett, MD Grynpas (2010) The long-term effects of water fluoridation on the human skeleton. Journal of Dental Research 89:1219-1223.
D Chachra, CH Turner, AJ Dunipace, MD Grynpas (1999) Calcified Tissue Research 64: 345-351.